Article

Single-cell sequencing of Entorhinal Cortex Reveals Wide-Spread Disruption of Neuropeptide Networks in Alzheimer’s Disease

2022-11-14

Abstract excerpt

Alzheimer’s disease (AD) is a fatal neurodegenerative disease that involves early and significant neuropathological changes within the entorhinal cortex (EC). Many have reported on neuronal loss and synaptic dysfunction in the brains of AD patients and AD models. In parallel, abnormalities of neuropeptides (NPs) that play important roles in modulating neuronal activities are commonly observed in AD and other neuro...

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Literature Corpus work: 283d7bb6-50f2-5a7e-8d41-a361d22b0d4a
DOI: 10.1101/2022.11.14.516160

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