Article

RNA-guided Retargeting of <i>Sleeping Beauty</i> Transposition in Human Cells

2019-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Two different approaches of genomic modification are currently used for genome engineering and gene therapy: integrating vectors, which can efficiently integrate large transgenes but are unspecific with respect to their integration sites, and nuclease-based approaches, which are highly specific but not efficient at integrating large genetic cargoes. Here we demonstrate biased genome-wide integra...

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Literature Corpus work: da1410c6-e6e3-5703-8157-99f7c3cc79b4
DOI: 10.1101/848309

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