Article

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

2019-12-10

Abstract excerpt

<h4>ABSTRACT</h4> α-Synuclein (α-syn) amyloid fibril, as the major component of Lewy bodies and pathological entity spreading in human brain, is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD. Here, we determined the cryo-EM structure of a full-length α-syn fibri...

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Literature Corpus work: 4dcb8dda-d9a3-5162-99df-9bc6e75bbf6d
DOI: 10.1101/870758

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