Article

Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation

2022-03-12

Abstract excerpt

Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA) have the same hallmark pathologic feature of misfolded α-synuclein protein accumulation in the brain. PD patients who carry α-syn hereditary mutations tend to have an earlier onset and more severe clinical symptoms and pathology than sporadic PD patients who carry wild-type (WT) α-syn. Therefo...

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Literature Corpus work: a2c6d835-1890-55d7-814f-f1c9182e3bf4
DOI: 10.1101/2022.03.11.483992

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