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Article

E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation.

Journal of chemical information and modeling - 14 Aug 2023

Huang Defa, Guo Cong

Abstract excerpt

Aggregation of α-synuclein is central to the pathogenesis of Parkinson's disease. The most toxic familial mutation E46K accelerates the aggregation process by an unknown mechanism. Herein, we provide a clue by investigating the influence of E46K on monomeric α-synuclein and its relation to aggregation with molecular dynamics simulations. The E46K mutation suppresses β-sheet structures in the N-terminus while...

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PMID: 37489886
DOI: 10.1021/acs.jcim.3c00694

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