Article

Cryo-EM structure of α-Synuclein Fibrils Harboring the Dementia with Lewy Bodies–Associated E83Q Mutation

2025-12-25

Abstract excerpt

Aggregation of α-synuclein (α-Syn) into amyloid fibrils underlies the pathology of synucleinopathies. Rare familial mutations can modulate α-Syn aggregation and may give rise to distinct fibril conformations linked to disease heterogeneity. The E83Q mutation, identified in a Dementia with Lewy Body disease (DLB) patient with atypical Lewy body distribution, has been shown to accelerate α-Syn aggregation and enhanc...

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Literature Corpus work: 3e34298c-ba33-541e-9399-f56be306765b
DOI: 10.64898/2025.12.23.696295

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