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Article

Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface.

The Journal of biological chemistry - 1 Apr 2023

Sun Chuanqi, Zhou Kang, DePaola Peter, Shin Woo Shik, Hillyer Trae, Sawaya Michael R, Zhu Ruowei, Peng Chao, Zhou Z Hong, Jiang Lin

Abstract excerpt

Synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple systems atrophy (MSA), have the same pathologic feature of misfolded α-synuclein protein (α-syn) accumulation in the brain. PD patients who carry α-syn hereditary mutations tend to have earlier onset and more severe clinical symptoms than sporadic PD patients. Therefore, revealing the effect of hereditary mutations to...

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Identifiers

PMID: 36871760
DOI: 10.1016/j.jbc.2023.104566
PMCID: PMC10124909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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