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Article

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.

PloS one - 1 Jan 2013

Lemkau Luisel R, Comellas Gemma, Lee Shin W, Rikardsen Lars K, Woods Wendy S, George Julia M, Rienstra Chad M

Abstract excerpt

Parkinson's disease (PD) is pathologically characterized by the presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra. These intracellular inclusions are largely composed of misfolded α-synuclein (AS), a neuronal protein that is abundant in the vertebrate brain. Point mutations in AS are associated with rare, early-onset forms of PD, although aggregation of the wild-type (WT) protein is...

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Identifiers

PMID: 23505409
DOI: 10.1371/journal.pone.0049750
PMCID: PMC3591419

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