Article

Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy

2024-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Multiple system atrophy (MSA) and Parkinson’s disease (PD) are caused by misfolded α-synuclein spreading throughout the central nervous system. While familial PD is linked to several point mutations in α-synuclein, there are no known mutations associated with MSA. Our previous work investigating differences in α-synuclein misfolding between the two disorders showed that the familial PD mutation...

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Literature Corpus work: f2a26054-c98b-540e-bb11-d6d4fb866b3f
DOI: 10.1101/2024.07.04.602104

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