Article
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation.
Cancer research - 5 Jul 2022
Huang Dan, Camacho Cristel V, Martire Sara, Nagari Anusha, Setlem Rohit, Gong Xuan, Edwards Andrea D, Chiu Shu-Ping, Banaszynski Laura A, Kraus W Lee
Abstract excerpt
Recent studies have identified cancer-associated mutations in histone genes that lead to the expression of mutant versions of core histones called oncohistones. Many oncohistone mutations occur at Asp and Glu residues, two amino acids known to be ADP-ribosylated (ADPRylated) by PARP1. We screened 25 Glu or Asp oncohistone mutants for their effects on cell growth in breast and ovarian cancer cells. Ectopic...
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