Article

Globular domain histone H3R131C mutation remodels chromatin accessibility to promote oncogenic transcriptional programs

2026-05-29

Abstract excerpt

Histone mutations, characterized as oncohistones, have emerged as important oncogenic driver events by altering chromatin structure and/or chromatin modifications, thereby dysregulating gene expression. While H3 tail domain oncohistone mutations such as H3K27M and H3K36M are well characterized, it is currently unknown whether mutations within the H3 globular domain represent oncogenic driver events. Using publicly...

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Literature Corpus work: c285abf1-d411-55e7-b753-565e70c684ae
DOI: 10.64898/2026.05.27.728333

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