Article
Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation.
Molecular cell - 18 Aug 2022
Mitchener Michelle M, Muir Tom W
Abstract excerpt
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now appreciated that somatic missense mutations in histones, the packaging agents of genomic DNA, are often associated with human pathologies, especially cancer. Although some of these "oncohistone" mutations are thought to be key drivers of cancer, the impacts of the majority of them on disease onset and progression remain to...
Topics
- Chromatin
- Epigenesis, Genetic
- Histones
- Humans
- Mutation
- Neoplasms