Article

Immunohistochemical Profiling of Histone Modification Biomarkers Identifies Subtype-Specific Epigenetic Signatures and Potential Drug Targets in Breast Cancer

2024-12-17

Abstract excerpt

<h4>Background: </h4> Breast cancer (BC) subtypes exhibit distinct epigenetic landscapes, with triple-negative breast cancer (TNBC) lacking effective targeted therapies. This study investigates histone biomarkers and therapeutic vulnerabilities across BC subtypes. <h4>Methods: </h4>: Immunohistochemical profiling of >20 histone biomarkers, including histone modifications, modifiers and oncohistone mutations was co...

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Literature Corpus work: 214c3767-4284-5a7c-9a06-bb796d95b475
DOI: 10.1101/2024.12.13.24318980

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