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Breast cancer genomic analyses reveal genes, mutations, and signaling networks.

Functional & integrative genomics - 4 Nov 2024

Manjunath Gowrang Kasaba, Sharma Srihari, Nashier Disha, Vasanthaiah Shruthi, Jha Spriha, Bage Saloni, Mitra Tamoghna, Goyal Pankaj, Neerathilingam Muniasamy, Kumar Abhishek

Abstract excerpt

Breast cancer (BC) is the most commonly diagnosed cancer and the predominant cause of death in women. BC is a complex disorder, and the exploration of several types of BC omic data, highlighting genes, perturbations, signaling and cellular mechanisms, is needed. We collected mutational data from 9,555 BC samples using cBioPortal. We classified 1174 BC genes (mutated ≥ 40 samples) into five tiers (BCtier_I-V) and...

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PMID: 39496981
DOI: 10.1007/s10142-024-01484-y

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