Article

Loss of function mutation in progressive ankylosis gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

2023-01-06

Abstract excerpt

<title>Abstract</title> <p>Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine triphosphate transporter, progressive ankylosis (ANK) is a regulator of extracellular inorganic pyrophosphate levels and plays an important role in tissue mineralization. However, the function of ANK in intervertebral disc has not bee...

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Literature Corpus work: 8b368ffd-d367-5bf0-a249-f9745610dbf3
DOI: 10.21203/rs.3.rs-2336837/v1

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