Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the progressive ankylosis gene in cartilage mineralization.

Current opinion in rheumatology - 1 Mar 2006

Zaka Raihana, Williams Charlene J

Abstract excerpt

PURPOSE OF REVIEW: Among the myriad of players in the calcification of cartilage, ANK is a relatively new entrant. It is a multipass transmembrane protein that regulates the transport of inorganic pyrophosphate between the cell and the extracellular space. Mutations in ANK result in two distinct calcification disorders: craniometaphyseal dysplasia and familial calcium pyrophosphate dihydrate deposition disease....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcinosis
Share to Cartilage, Articular
Share to Diphosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Growth Plate

Share to Mutation

Share to Phosphate Transport Proteins

Source

Identifiers

PMID: 16462526
DOI: 10.1097/01.bor.0000209432.36355.6e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the progressive ankylosis gene in cartilage mineralization.PMID 16462526Read ↗

The role of ANKH in pathologic mineralization of cartilage.Semantic proximity Read ↗

The Role of ANK in Calcium Pyrophosphate Deposition Disease.Semantic proximity Read ↗

Role of the mouse ank gene in control of tissue calcification and arthritis.Semantic proximity Read ↗

Pathophysiology of articular chondrocalcinosis--role of ANKH.Semantic proximity Read ↗

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read ↗

Loss of function mutation in progressive ankylosis gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral discSemantic proximity Read ↗

Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia.Semantic proximity Read ↗

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.Semantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

Bone Mineralization Regulation: Using Zebrafish as a Model to Study ANKH-associated Mineralization DisordersSemantic proximity Read ↗

A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).Semantic proximity Read ↗

Mineral formation in joints caused by complete or joint-specific loss of ANK function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.