Article
Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.
Cell death & disease - 19 Jul 2023
Ohnishi Takashi, Tran Victoria, Sao Kimheak, Ramteke Pranay, Querido William, Barve Ruteja A, van de Wetering Koen, Risbud Makarand V
Abstract excerpt
Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine triphosphate efflux transporter, progressive ankylosis (ANK) is a regulator of extracellular inorganic pyrophosphate levels and plays an important role in tissue mineralization. However, the function of ANK in intervertebral disc has not been fully explored....
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