Article

Bone Mineralization Regulation: Using Zebrafish as a Model to Study ANKH-associated Mineralization Disorders

2024-03-26

Abstract excerpt

Craniometaphyseal Dysplasia (CMD) is a rare skeletal disorder that can result from mutations in the ANKH gene. This gene encodes progressive ankylosis (ANK), which is responsible for transporting inorganic pyrophosphate (PPi) and ATP from the intracellular to the extracellular environment, where PPi inhibits bone mineralization. When ANK is dysfunctional, as in patients with CMD, the passage of PPi to the extrace...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56826f76-3f98-5091-86f6-a17ffb229ba2
DOI: 10.1101/2024.03.21.586098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bone Mineralization Regulation: Using Zebrafish as a Model to Study ANKH-associated Mineralization DisordersDOI 10.1101/2024.03.21.586098Read

The role of ANKH in pathologic mineralization of cartilage.Semantic proximity Read

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read

[Research Advances of Human Homologue of Mouse Progressive Ankylosis Protein and Bone and Joint Diseases].Semantic proximity Read

Role of the progressive ankylosis gene in cartilage mineralization.Semantic proximity Read

Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia.Semantic proximity Read

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read

A bone to pick with zebrafishSemantic proximity Read

Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).Semantic proximity Read

A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).Semantic proximity Read

Mineral formation in joints caused by complete or joint-specific loss of ANK function.Semantic proximity Read

Introduction of a Phe377del Mutation in ANK Creates a Mouse Model for Craniometaphyseal DysplasiaSemantic proximity Read

Role of the mouse ank gene in control of tissue calcification and arthritis.Semantic proximity Read