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Article

The role of ANKH in pathologic mineralization of cartilage.

Current opinion in rheumatology - 1 Mar 2016

Williams Charlene J

Abstract excerpt

PURPOSE OF REVIEW: ANKH is the human homolog of a gene whose dysfunction in a mutant mouse strain results in progressive ankylosis of the spine as well as soft tissue mineralization. ANKH mutations have been reported in inherited human disorders such as familial calcium pyrophosphate deposition disease (CPPD) and cranial metaphyseal dysplasia; however, research into the function of the ANKH protein has been more...

Topics

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Calcinosis
Cartilage, Articular
Cell Differentiation
Chondrocytes
Chondrogenesis
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphate Transport Proteins

Signal Transduction

Source

Identifiers

PMID: 26599446
DOI: 10.1097/BOR.0000000000000247

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

The role of ANKH in pathologic mineralization of cartilage.PMID 26599446Read ↗

Role of the progressive ankylosis gene in cartilage mineralization.Semantic proximity Read ↗

Bone Mineralization Regulation: Using Zebrafish as a Model to Study ANKH-associated Mineralization DisordersSemantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read ↗

Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia.Semantic proximity Read ↗

A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).Semantic proximity Read ↗

Pathophysiology of articular chondrocalcinosis--role of ANKH.Semantic proximity Read ↗

Mineral formation in joints caused by complete or joint-specific loss of ANK function.Semantic proximity Read ↗

Role of the mouse ank gene in control of tissue calcification and arthritis.Semantic proximity Read ↗

Extracellular pyrophosphate in the kidney: how does it get there and what does it do?.Semantic proximity Read ↗

Loss of function mutation in progressive ankylosis gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral discSemantic proximity Read ↗

The Role of ANK in Calcium Pyrophosphate Deposition Disease.Semantic proximity Read ↗

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