Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of ANK in Calcium Pyrophosphate Deposition Disease.

Current rheumatology reports - 1 May 2016

Mitton-Fitzgerald Elizabeth, Gohr Claudia M, Bettendorf Brittany, Rosenthal Ann K

Abstract excerpt

The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Phosphate Transport Proteins
Share to Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 27032788
DOI: 10.1007/s11926-016-0574-z
PMCID: PMC5453179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of ANK in Calcium Pyrophosphate Deposition Disease.PMID 27032788Read ↗

Role of the progressive ankylosis gene in cartilage mineralization.Semantic proximity Read ↗

Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene.Semantic proximity Read ↗

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read ↗

Role of the mouse ank gene in control of tissue calcification and arthritis.Semantic proximity Read ↗

The role of ANKH in pathologic mineralization of cartilage.Semantic proximity Read ↗

Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia.Semantic proximity Read ↗

Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK.Semantic proximity Read ↗

Pathophysiology of articular chondrocalcinosis--role of ANKH.Semantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

Expression and localisation of the pyrophosphate transporter, ANK, in murine kidney cells.Semantic proximity Read ↗

Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH.Semantic proximity Read ↗

P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.