Article

Targeted modulation of phosphate and lipid metabolism reduces ligament mineralization in col9a1b knockout models

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Intervertebral disc degeneration (IVDD) is a major global cause of chronic back pain and disability in the aging population, characterized by disc matrix breakdown, ligament mineralization, and pain. Effective pharmacological treatments for IVDD are currently unavailable. We used col9a1b mutant zebrafish to elucidate the genetic and molecular mechanisms of disc disease, with a focus on...

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Literature Corpus work: a359ecd4-ab01-525e-833f-148be1c6b29d
DOI: 10.21203/rs.3.rs-7082517/v1

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