Article

<i>Abcc6</i> null mice a model for mineralization disorder PXE show vertebral osteopenia without enhanced intervertebral disc calcification with aging

2021-11-20

Abstract excerpt

Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging is dystrophic calcification. ATP-binding cassette sub-family C member 6 (ABCC6), a presumed ATP efflux transporter, is a key regulator of systemic levels of the mineralization inhibitor pyrophosphate (PPi). Mutat...

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Identifiers and source

Literature Corpus work: 6729f2f5-1500-585a-882a-e470fd7e7e5e
DOI: 10.1101/2021.11.17.468924

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