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Article

Mineral formation in joints caused by complete or joint-specific loss of ANK function.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2006

Gurley Kyle A, Chen Hao, Guenther Catherine, Nguyen Elizabeth T, Rountree Ryan B, Schoor Michael, Kingsley David M

Abstract excerpt

UNLABELLED: To reveal the ANK complete loss of function phenotype in mice, we generated conditional and null alleles. Mice homozygous for the null allele exhibited widespread joint mineralization, similar in severity to animals harboring the original ank allele. A delayed yet similar phenotype was observed in mice with joint-specific loss of ANK function. INTRODUCTION: The ANK pyrophosphate regulator was...

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Topics

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Share to Cartilage, Articular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Proteins

Share to Mice, Knockout

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Share to Tomography, X-Ray Computed

Source

Identifiers

PMID: 16869722
DOI: 10.1359/jbmr.060515

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

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Mineral formation in joints caused by complete or joint-specific loss of ANK function.PMID 16869722Read ↗

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The role of ANKH in pathologic mineralization of cartilage.Semantic proximity Read ↗

Role of the progressive ankylosis gene in cartilage mineralization.Semantic proximity Read ↗

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Introduction of a Phe377del Mutation in ANK Creates a Mouse Model for Craniometaphyseal DysplasiaSemantic proximity Read ↗

Loss of function mutation in progressive ankylosis gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral discSemantic proximity Read ↗

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.Semantic proximity Read ↗

Autosomal recessive mental retardation, deafness, ankylosis, and mild hypophosphatemia associated with a novel ANKH mutation in a consanguineous family.Semantic proximity Read ↗

Aberrant chondrocyte hypertrophy and activation of β-catenin signaling precede joint ankylosis in ank/ank mice.Semantic proximity Read ↗

[Research Advances of Human Homologue of Mouse Progressive Ankylosis Protein and Bone and Joint Diseases].Semantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

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