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Article

Role of the mouse ank gene in control of tissue calcification and arthritis.

Science (New York, N.Y.) - 14 Jul 2000

Ho A M, Johnson M D, Kingsley D M

Abstract excerpt

Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in...

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Identifiers

PMID: 10894769
DOI: 10.1126/science.289.5477.265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10894769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Role of the mouse ank gene in control of tissue calcification and arthritis.PMID 10894769Read ↗

Role of the progressive ankylosis gene in cartilage mineralization.Semantic proximity Read ↗

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read ↗

Mineral formation in joints caused by complete or joint-specific loss of ANK function.Semantic proximity Read ↗

The role of ANKH in pathologic mineralization of cartilage.Semantic proximity Read ↗

The Role of ANK in Calcium Pyrophosphate Deposition Disease.Semantic proximity Read ↗

[Research Advances of Human Homologue of Mouse Progressive Ankylosis Protein and Bone and Joint Diseases].Semantic proximity Read ↗

Progressive ankylosis, a new skeletal mutation in the mouse.Semantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells.Semantic proximity Read ↗

Loss of function mutation in progressive ankylosis gene causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral discSemantic proximity Read ↗

Autosomal recessive mental retardation, deafness, ankylosis, and mild hypophosphatemia associated with a novel ANKH mutation in a consanguineous family.Semantic proximity Read ↗

Bone Mineralization Regulation: Using Zebrafish as a Model to Study ANKH-associated Mineralization DisordersSemantic proximity Read ↗

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