Article

The transcriptomic landscape of normal and ineffective erythropoiesis at single cell resolution

2022-08-02

Abstract excerpt

Ineffective erythropoiesis, the death of maturing erythroid cells, is a common cause of anemia. To better understand why this occurs, we studied the fates and adaptations of single erythroid marrow cells from individuals with Diamond Blackfan anemia (DBA), del(5q) myelodysplastic syndrome (del(5q) MDS), and normal controls, and defined an unhealthy (vs. healthy) differentiation trajectory, using velocity pseudotim...

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Literature Corpus work: 8ad84059-8fd9-5fbc-bbb3-43dec6e4008b
DOI: 10.1101/2022.08.01.22278133

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