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The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution

23 Jun 2023

Abstract excerpt

The anemias of myelodysplastic syndrome (MDS) and Diamond Blackfan anemia (DBA) are generally macrocytic and always reflect ineffective erythropoiesis yet result from diverse genetic mutations. To delineate shared mechanisms that lead to cell death, we studied the fate of single erythroid marrow cells from individuals with DBA or MDS-5q. We defined an unhealthy (vs healthy) differentiation trajectory using...

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PMID: 37352261
DOI: 10.1182/bloodadvances.2023010382

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