Article

Single-cell and bulk transcriptomic analyses identify HSP90AA1- associated oxidative stress adaptation during impaired erythroid differentiation in β-thalassemia

2026-08-13

Abstract excerpt

<title>Abstract</title> <p>β-thalassemia is characterized by defective β-globin synthesis, chronic oxidative stress, and ineffective erythropoiesis. However, the cellular heterogeneity and molecular responses underlying these processes remain incompletely defined. In this study, we reanalyzed publicly available single-cell and bulk transcriptomic datasets to investigate oxidative stress–associated erythroid remod...

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Literature Corpus work: 34301677-97c5-5e77-bc96-63b36e57d39f
DOI: 10.21203/rs.3.rs-10521726/v1

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