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Molecular and cellular mechanisms that regulate human erythropoiesis

22 Dec 2021

Abstract excerpt

To enable effective oxygen transport, ∼200 billion red blood cells (RBCs) need to be produced every day in the bone marrow through the fine-tuned process of erythropoiesis. Erythropoiesis is regulated at multiple levels to ensure that defective RBC maturation or overproduction can be avoided. Here, we provide an overview of different layers of this control, ranging from cytokine signaling mechanisms that enable...

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PMID: 34936695
DOI: 10.1182/blood.2021011044

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