Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics.

Genetics - 15 Apr 2021

Yankovitz Gal, Cohn Ofir, Bacharach Eran, Peshes-Yaloz Naama, Steuerman Yael, Iraqi Fuad A, Gat-Viks Irit

Abstract excerpt

Recent computational methods have enabled the inference of the cell-type-specificity of eQTLs based on bulk transcriptomes from highly heterogeneous tissues. However, these methods are limited in their scalability to highly heterogeneous tissues and limited in their broad applicability to any cell-type specificity of eQTLs. Here we present and demonstrate Cell Lineage Genetics (CeL-Gen), a novel computational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Quantitative Trait Loci

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 33734353
DOI: 10.1093/genetics/iyab016
PMCID: PMC8049554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics.PMID 33734353Read ↗

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte DifferentiationSemantic proximity Read ↗

CellRegMap: A statistical framework for mapping context-specific regulatory variants using scRNA-seqSemantic proximity Read ↗

eQTL studies: from bulk tissues to single cells.Semantic proximity Read ↗

Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping.Semantic proximity Read ↗

Cell type specific genetic regulation of gene expression across human tissuesSemantic proximity Read ↗

Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mappingSemantic proximity Read ↗

The single-cell eQTLGen consortium.Semantic proximity Read ↗

DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms.Semantic proximity Read ↗

A computational method for Cell type-specific Expression Quantitative Trait Loci mapping using bulk RNA-seq dataSemantic proximity Read ↗

A unified framework for cell-type-specific eQTL prioritization by integrating bulk and scRNA-seq data.Semantic proximity Read ↗

Protocol for identifying cell-type-specific genes associated with disease risk using single-cell eQTL data.Semantic proximity Read ↗

A computational method for cell type-specific expression quantitative trait loci mapping using bulk RNA-seq data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.