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Determining cell fate specification and genetic contribution to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution

2017-12-05

Abstract excerpt

The majority of genetic loci underlying common disease risk act through changing genome regulation, and are routinely linked to expression quantitative trait loci, where gene expression is measured using bulk populations of mature cells. A crucial step that is missing is evidence of variation in the expression of these genes as cells progress from a pluripotent to mature state. This is especially important for car...

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Literature Corpus work
3b7b6823-eedf-503c-b714-106b9f3d4bfd
DOI
10.1101/229336
Open publication

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