Article

Mapping the landscape of lineage-specific dynamic regulation of gene expression using single-cell transcriptomics and application to genetics of complex disease

2023-10-25

Abstract excerpt

Single-cell transcriptome data can provide insights into how genetic variation influences biological processes involved in human biology and disease. However, the identification of gene-level associations in distinct cell types faces several challenges, including the limited reference resource from population scale studies, data sparsity in single-cell RNA sequencing, and the complex cell-state pattern of expressi...

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Literature Corpus work: 3c5272e5-b1aa-51d4-a575-2f9d5881d80e
DOI: 10.1101/2023.10.24.23297476

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