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Single-cell network biology for resolving cellular heterogeneity in human diseases.

Experimental & molecular medicine - 1 Nov 2020

Cha Junha, Lee Insuk

Abstract excerpt

Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells harboring identical genomes show a wide variety of behaviors in multicellular organisms. Genetic circuits underlying cell-type identities will facilitate the understanding of the regulatory programs for differentiation and maintenance of distinct cellular states. Such a cell-type-specific gene network can be inferred from...

Topics

Computational Biology
Disease Susceptibility
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Genetic Heterogeneity
Genetic Predisposition to Disease
Humans
Single-Cell Analysis
Transcriptome

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PMID: 33244151
DOI: 10.1038/s12276-020-00528-0
PMCID: PMC8080824

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