Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer.

Scientific reports - 25 Oct 2019

Lello Louis, Raben Timothy G, Yong Soke Yuen, Tellier Laurent C A M, Hsu Stephen D H

Abstract excerpt

We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank. Among the disease conditions studied are Hypothyroidism, (Resistant) Hypertension, Type 1 and 2 Diabetes, Breast Cancer, Prostate Cancer, Testicular Cancer,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Algorithms

Share to Diabetes Mellitus, Type 1

Share to Myocardial Infarction

Share to Prostatic Neoplasms

Share to Risk Assessment

Share to ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 31653892
DOI: 10.1038/s41598-019-51258-x
PMCID: PMC6814833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer.PMID 31653892Read ↗

Genomic Prediction of Complex Disease RiskSemantic proximity Read ↗

Genetic risk prediction in complex disease.Semantic proximity Read ↗

Significant Sparse Polygenic Risk Scores across 813 traits in UK BiobankSemantic proximity Read ↗

Significant sparse polygenic risk scores across 813 traits in UK Biobank.Semantic proximity Read ↗

Integrating polygenic and transcriptional risk scores improves risk prediction of nine common diseases in the underrepresented Vietnamese populationSemantic proximity Read ↗

Efficient implementation of penalized regression for genetic risk predictionSemantic proximity Read ↗

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants.Semantic proximity Read ↗

Rare-variant risk scores complement common-variant polygenic scores for disease risk prediction and stratificationSemantic proximity Read ↗

Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models.Semantic proximity Read ↗

Performance and robustness of penalized and unpenalized methods for genetic prediction of complex human disease.Semantic proximity Read ↗

Genetic architecture of complex traits and disease risk predictors.Semantic proximity Read ↗

Genetic Architecture of Complex Traits and Disease Risk PredictorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.