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Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

18 Feb 2022

Abstract excerpt

A polygenic risk score estimates the genetic risk of an individual for some disease or trait, calculated by aggregating the effect of many common variants associated with the condition. With the increasing availability of genetic data in large cohort studies such as the UK Biobank, inclusion of this genetic risk as a covariate in statistical analyses is becoming more widespread. Previously this required...

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PMID: 35251129
DOI: 10.3389/fgene.2022.818574

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