Article

Astrocytic FMRP regulates the function of spinal parvalbumin-expressing neurons in Fragile X Syndrome

2026-07-19

Abstract excerpt

Tactile hypersensitivity is a common symptom of Fragile X Syndrome (FXS) characterized by over-responsiveness to innocuous touch or textures. Yet, the neural circuitry underlying this altered sensory processing remains incompletely understood. Previous studies have focused on cortical and peripheral neuron dysfunction. However, the spinal dorsal horn circuits, which make up the first central site of somatosensory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8abc9709-5476-5419-ada0-d0b7079a58f7
DOI: 10.64898/2026.07.17.737291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Astrocytic FMRP regulates the function of spinal parvalbumin-expressing neurons in Fragile X SyndromeDOI 10.64898/2026.07.17.737291Read

Hypoplasticity in sensory-driven necortical circuits of Fragile X miceSemantic proximity Read

Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Semantic proximity Read

Homeostatic Inhibitory Control of Cortical Hyperexcitability in Fragile X SyndromeSemantic proximity Read

Hyperexcitability in the olfactory bulb and impaired fine odor discrimination in the <i>Fmr1</i> KO mouse model of fragile X syndromeSemantic proximity Read

Impaired inhibitory control of cortical synchronization in fragile X syndrome.Semantic proximity Read

Astrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndromeSemantic proximity Read

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRPSemantic proximity Read

Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice.Semantic proximity Read

Higher hyperpolarization activated current (I <sub>h</sub> ) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X miceSemantic proximity Read

<i>FMR1</i> loss results in early changes to intrinsic membrane excitability in human cellular modelsSemantic proximity Read

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.Semantic proximity Read

Enhanced Ba <sup>2+</sup> -sensitive inward rectifying potassium conductance reduces intrinsic excitability of layer 2/3 pyramidal neurons in the primary auditory cortex of Fmr1 knockout miceSemantic proximity Read