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Article

Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.

Nature communications - 23 Oct 2019

Domanski Aleksander P F, Booker Sam A, Wyllie David J A, Isaac John T R, Kind Peter C

Abstract excerpt

Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular and synaptic properties of layer 4 neurons combined with cellular and network simulations, we explored how the array...

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Identifiers

PMID: 31645553
DOI: 10.1038/s41467-019-12736-y
PMCID: PMC6811545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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