Back to search

Article

Enhanced Ba <sup>2+</sup> -sensitive inward rectifying potassium conductance reduces intrinsic excitability of layer 2/3 pyramidal neurons in the primary auditory cortex of Fmr1 knockout mice

2026-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS) is frequently associated with auditory hypersensitivity and altered cortical processing, yet the intrinsic ionic mechanisms shaping auditory cortex excitability remain incompletely defined. Here, we tested whether subthreshold conductances contribute to compensatory changes in intrinsic excitability in layer 2/3 (L2/3) pyramidal neurons of the primary auditory cortex (AC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
88abc1d8-a541-58af-8d0b-bfccb915432c
DOI
10.64898/2026.02.03.703439
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Enhanced Ba <sup>2+</sup> -sensitive inward rectifying potassium conductance reduces intrinsic excitability of layer 2/3 pyramidal neurons in the primary auditory cortex of Fmr1 knockout miceDOI 10.64898/2026.02.03.703439
Higher hyperpolarization activated current (I <sub>h</sub> ) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X miceSemantic proximity
Hyperexcitability and loss of feedforward inhibition in the <i>Fmr1</i> KO lateral amygdalaSemantic proximity
The paradoxical effects of K <sup>+</sup> channel gain-of-function are mediated by GABAergic neuron hypoexcitability and hyperconnectivitySemantic proximity
<i>FMR1</i> loss results in early changes to intrinsic membrane excitability in human cellular modelsSemantic proximity
Hyperexcitability in the olfactory bulb and impaired fine odor discrimination in the <i>Fmr1</i> KO mouse model of fragile X syndromeSemantic proximity
Altered auditory maturation in Fragile X syndrome and its involvement in audiogenic seizure susceptibilitySemantic proximity
Biophysical characterization and modeling of <i>SCN1A</i> gain-of-function predicts interneuron hyperexcitability and a predisposition to network instability through homeostatic plasticitySemantic proximity
Hypoplasticity in sensory-driven necortical circuits of Fragile X miceSemantic proximity
Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet SyndromeSemantic proximity
Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability.Semantic proximity
Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neuronsSemantic proximity
Homeostatic Inhibitory Control of Cortical Hyperexcitability in Fragile X SyndromeSemantic proximity
Select a neighboring publication to make it the new centre.