Article

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

2021-06-25

Abstract excerpt

Reduced structural and functional interhemispheric connectivity correlates with the severity of Autism Spectrum Disorder (ASD) behaviors in humans. Little is known of how ASD-risk genes regulate callosal connectivity. Here we show that Fmr1 , whose loss-of-function leads to Fragile X Syndrome (FXS), cell autonomously promotes maturation of callosal excitatory synapses between somatosensory barrel cortices in mice...

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Literature Corpus work: 409d607f-d32b-5421-b9a0-1dadaef632bb
DOI: 10.1101/2021.06.25.449490

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