Article

<i>FMR1</i> loss results in early changes to intrinsic membrane excitability in human cellular models

2020-01-29

Abstract excerpt

Fragile X mental retardation 1 (FMR1) encodes the RNA binding protein FMRP. Loss of FMRP drives Fragile X syndrome (FXS), the leading inherited cause of intellectual disability and a leading monogenic cause of autism. Cortical hyperexcitability is a hallmark of FXS, however, the underlying mechanisms reported, including alterations in synaptic transmission and ion channel expression and properties, are heterogeneo...

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Literature Corpus work: c088d339-2c5c-5362-92c4-bd0c12006ad6
DOI: 10.1101/2020.01.28.923425

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