Article

Homeostatic Inhibitory Control of Cortical Hyperexcitability in Fragile X Syndrome

2018-11-01

Abstract excerpt

In mouse models of Fragile X Syndrome (FXS), cellular and circuit hyperexcitability are a consequence of altered brain development [reviewed in (Contractor et al., 2015)]. Mechanisms that favor or hinder plasticity of synapses could affect neuronal excitability. This includes inhibitory long term depression (I-LTD) – a heterosynaptic form of plasticity that requires the activation of metabotropic glutamate recepto...

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Literature Corpus work: f60c1083-81d8-5e27-bd94-72a01150d173
DOI: 10.1101/459511

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