Article
Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice.
The Journal of physiology - 15 Sept 2003
Graham B A, Schofield P R, Sah P, Callister R J
Abstract excerpt
The spastic (spa) and oscillator (ot) mouse have naturally occurring mutations in the inhibitory glycine receptor (GlyR) and exhibit severe motor disturbances when exposed to unexpected sensory stimuli. We examined the effects of the spa and ot mutations on GlyR- and GABAAR-mediated synaptic transmission in the superficial dorsal horn (SFDH), a spinal cord region where inhibition is important for nociceptive...
Topics
- Animals
- Female
- Genotype
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Muscle Spasticity
- Neural Inhibition
- Patch-Clamp Techniques
- Posterior Horn Cells
- Receptors, GABA-A
- Receptors, Glycine
- Synaptic Transmission