Convergent Evolution in Tumor Genomes Targets Functional Domains

Abstract excerpt

Tumor evolution is shaped by selective pressures that repeatedly favor similar functional outcomes across genetically distinct cancers. While convergent evolution in cancer has been studied at the gene level, this work investigates selection on smaller functional units, namely protein domains. Using >9,500 primary tumor exomes from The Cancer Genome Atlas, we quantified selection strengths acting on missense and t...

Topics

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• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation Rate
• Neoplasms
• Point Mutation
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

8a91d01d-8c9f-59b1-ac34-ab2a8ad475ef

DOI

10.64898/2026.05.31.729131