Article
Deep phylogeny of cancer drivers and compensatory mutations.
Communications biology - 2 Oct 2020
Rochman Nash D, Wolf Yuri I, Koonin Eugene V
Abstract excerpt
Driver mutations (DM) are the genetic impetus for most cancers. The DM are assumed to be deleterious in species evolution, being eliminated by purifying selection unless compensated by other mutations. We present deep phylogenies for 84 cancer driver genes and investigate the prevalence of 434 DM across gene-species trees. The DM are rare in species evolution, and 181 are completely absent, validating their...
Topics
- Animals
- Evolution, Molecular
- Genes, Neoplasm
- Genes, Tumor Suppressor
- Humans
- Mutation
- Neoplasms
- Oncogenes
- Phylogeny
- Sequence Alignment