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Article

Universal Patterns of Selection in Cancer and Somatic Tissues.

Cell - 16 Nov 2017

Martincorena Iñigo, Raine Keiran M, Gerstung Moritz, Dawson Kevin J, Haase Kerstin, Van Loo Peter, Davies Helen, Stratton Michael R, Campbell Peter J

Abstract excerpt

Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs negative selection during cancer development. On average, <1 coding base substitution/tumor is lost through negative...

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Identifiers

PMID: 29056346
DOI: 10.1016/j.cell.2017.09.042
PMCID: PMC5720395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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