Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains.

BMC bioinformatics - 16 Aug 2017

Hashemi Seirana, Nowzari Dalini Abbas, Jalali Adrin, Banaei-Moghaddam Ali Mohammad, Razaghi-Moghadam Zahra

Abstract excerpt

BACKGROUND: Discriminating driver mutations from the ones that play no role in cancer is a severe bottleneck in elucidating molecular mechanisms underlying cancer development. Since protein domains are representatives of functional regions within proteins, mutations on them may disturb the protein functionality. Therefore, studying mutations at domain level may point researchers to more accurate assessment of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Internet

Share to Mitochondria

Share to Neoplastic Stem Cells

Share to Protein Interaction Maps

Share to Proteins

Share to User-Computer Interface

Source

Open in PubMed Open full text

Identifiers

PMID: 28814324
DOI: 10.1186/s12859-017-1779-5
PMCID: PMC5559820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains.PMID 28814324Read ↗

Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples.Semantic proximity Read ↗

Protein domain-level landscape of cancer-type-specific somatic mutations.Semantic proximity Read ↗

Mutational oncogenic signatures on structurally resolved protein interacting interfacesSemantic proximity Read ↗

Convergent Evolution in Tumor Genomes Targets Functional DomainsSemantic proximity Read ↗

Looking Across Protein Domains to Identify Driver Mutations in CancerSemantic proximity Read ↗

Integrating evidence from protein domains to identify cancer driver mutations.Semantic proximity Read ↗

Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development.Semantic proximity Read ↗

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.Semantic proximity Read ↗

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read ↗

A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces.Semantic proximity Read ↗

Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer typesSemantic proximity Read ↗

Systematic identification of significantly mutated regions reveals a rich landscape of functional molecular alterations across cancer genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.