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Article

DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy.

Nature communications - 13 May 2025

Khalil Ahmed, Supek Fran

Abstract excerpt

Somatic cells can transform into tumors due to mutations, and the tumors further evolve towards increased aggressiveness and therapy resistance. We develop DiffInvex, a framework for identifying changes in selection acting on individual genes in somatic genomes, drawing on an empirical mutation rate baseline derived from non-coding DNA that accounts for shifts in neutral mutagenesis during cancer evolution. We...

Read the complete abstract on PubMed

Topics

Humans
Neoplasms
Drug Resistance, Neoplasm
Carcinogenesis
Evolution, Molecular
Antineoplastic Agents
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Point Mutation

Mutation Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 40360478
DOI: 10.1038/s41467-025-59397-8
PMCID: PMC12075687

Genes

APC
ARID1A
MAP2K4
MAP3K1
NOTCH1
PIK3CA
SMAD4
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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