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Article

Protein domain-level landscape of cancer-type-specific somatic mutations.

PLoS computational biology - 1 Mar 2015

Yang Fan, Petsalaki Evangelia, Rolland Thomas, Hill David E, Vidal Marc, Roth Frederick P

Abstract excerpt

Identifying driver mutations and their functional consequences is critical to our understanding of cancer. Towards this goal, and because domains are the functional units of a protein, we explored the protein domain-level landscape of cancer-type-specific somatic mutations. Specifically, we systematically examined tumor genomes from 21 cancer types to identify domains with high mutational density in specific...

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Identifiers

PMID: 25794154
DOI: 10.1371/journal.pcbi.1004147
PMCID: PMC4368709

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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