Article
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource.
Genome biology - 26 Jan 2022
Dressler Lisa, Bortolomeazzi Michele, Keddar Mohamed Reda, Misetic Hrvoje, Sartini Giulia, Acha-Sagredo Amelia, Montorsi Lucia, Wijewardhane Neshika, Repana Dimitra, Nulsen Joel, Goldman Jacki, Pollitt Marc, Davis Patrick, Strange Amy, Ambrose Karen, Ciccarelli Francesca D
Abstract excerpt
BACKGROUND: Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development. RESULTS: Here, we collect a literature-based repertoire of 3355 well-known or predicted drivers of cancer and non-cancer somatic evolution in 122 cancer types and...
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