Article

Identification of Genes under Purifying Selection in Human Cancers

2017-04-20

Abstract excerpt

There is widespread interest in finding therapeutic vulnerabilities by analyzing the somatic mutations in cancers. Most analyses have focused on identifying driver oncogenes mutated in patient tumors, but this approach is incapable of discovering genes essential for tumor growth yet not activated through mutation. We show that such genes can be systematically discovered by mining cancer sequencing data for evidenc...

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Literature Corpus work: 11afdd0b-b6ed-5c19-9226-1c56a4450260
DOI: 10.1101/129205

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