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Article

Competing interactions stabilize pro- and anti-aggregant conformations of human Tau.

The Journal of biological chemistry - 10 Jun 2011

Wegmann Susanne, Schöler Jonas, Bippes Christian A, Mandelkow Eckhard, Muller Daniel J

Abstract excerpt

Aggregation of Tau into amyloid-like fibrils is a key process in neurodegenerative diseases such as Alzheimer. To understand how natively disordered Tau stabilizes conformations that favor pathological aggregation, we applied single-molecule force spectroscopy. Intramolecular interactions that fo...

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Identifiers

PMID: 21498513
DOI: 10.1074/jbc.M111.237875
PMCID: PMC3121454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21498513-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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